Synthesis and antibacterial activity of 4-benzoyl-1-(4-carboxy-phenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid and derivatives

Bildirici İ. , ŞENER A., ATALAN E., Battal A. , Genç H.

MEDICINAL CHEMISTRY RESEARCH, cilt.18, ss.327-340, 2009 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 18 Konu: 5
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1007/s00044-008-9130-3
  • Sayfa Sayıları: ss.327-340


A new 1H-pyrazole-3-carboxylic acid 2, along with hydrazono-pyridazinone 3, a by-product, and its derivatives 4-7 were synthesized and the structures confirmed by infrared (IR) and H-1 and C-13 nuclear magnetic resonance (NMR) data. These new compounds were evaluated for their antibacterial activities against Gram-positive and Gram-negative bacteria using the tube dilution method. The minimal inhibitory concentrations (MICs) experiments revealed that most compounds exerted inhibitor effects against Klebsiella pneumonia, Escherichia coli, Bacillus subtilus, and Xanthomonas compestris test microorganisms. Moreover, the results showed that the pyrazolo[3,4-d]pyridazine compounds were the best compounds of the series, exhibiting antibacterial activity against both Gram-positive and Gram-negative bacteria.