A lamotrigine induced toxic epidermal necrolysis in a child

CALKA O., KARADAG A., Bilgili S., Bulut G., ALTUN F., Burakgazi A.

CUTANEOUS AND OCULAR TOXICOLOGY, vol.32, no.1, pp.86-88, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.3109/15569527.2012.662253
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.86-88
  • Van Yüzüncü Yıl University Affiliated: Yes


Toxic epidermal necrolysis (TEN) is rare, life-threatening skin disorder that usually is caused by an adverse drug reaction. The exact pathogenesis of TEN is still unknown. Many treatments including prednisolone, cyclosporine and intravenous immunoglobulin (IVIG) can be used to halt the disease process. We present a 12-year-old girl with epilepsy who developed TEN after about 14 days of lamotrigine treatment. Lamotrigine was immediately discontinued. After receiving systemic corticosteroid treatment, the patient had a complete recovery. Antiepileptic-induced TEN can be mortal in some cases. Thus, we would like to point out the importance of early diagnosis and treatment.