Electrochemical Determination of Fluoroquinolone Antibiotic Norfloxacin in the Presence of Anionic Surfactant Using the Anodically Pretreated Boron-Doped Diamond Electrode


Karahan F., Basi Z., Keskin E., Pinar P. T. , Yardım Y. , Şentürk Z.

CHEMISTRYSELECT, cilt.5, ss.12862-12868, 2020 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 5 Konu: 42
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1002/slct.202002921
  • Dergi Adı: CHEMISTRYSELECT
  • Sayfa Sayıları: ss.12862-12868

Özet

In this article, a simple, fast and inexpensive methodology has been developed for the determination of fluoroquinolone class antibiotic norfloxacin (NFX) in anionic surfactant media (sodium dodecyl sulphate, SDS) using an anodically pretreated boron-doped diamond (APT-BDD) electrode. Cyclic voltammetric studies showed that the NFX gave an irreversible and adsorption controlled anodic oxidation signal at a potential of about +1.32 V on the APT-BDD electrode. The effects of parameters such as the electrode pre-treatment procedure, SDS concentration, and instrumental variables on the electrochemical sensitivity of NFX were evaluated. Under optimized conditions, the linearity was achieved in the range of 0.05 to 4.0 mu g mL(-1) (1.57x10(-7)-1.25x10(-5) mol L-1), with a detection limit of 0.013 mu g mL(-1) (4.07x10(-8) mol L-1) by using square-wave adsorptive stripping voltammetry (SW-AdSV). The feasibility of the developed approach for the quantification of NFX in urine samples was tested.