Plantago major Protective Effects on Antioxidant Status after Administration of 7,12-Dimethylbenz(a)anthracene in Rats


Oto G. , Ekin S. , OZDEMIR H. , Demir H. , Yasar S. , Levent A., ...More

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, vol.12, no.2, pp.531-535, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 2
  • Publication Date: 2011
  • Title of Journal : ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
  • Page Numbers: pp.531-535
  • Keywords: Antioxidant, DMBA, lipid peroxidation, plantago major, rat, CARBONIC-ANHYDRASE, OXIDATIVE STRESS, MEDICINAL-PLANTS, CELL-DEATH, CANCER, DMBA, CARCINOGENESIS, INHIBITION, SELENIUM

Abstract

Aim: The present study was designed to evaluate effects of Plantago major extract on oxidative status in Wistar albino rats administrated 7,12-dimethylbenz(a)anthracene (DMBA). Methods: Rats were divided into three equal groups of 6 animals each: Group 1 controls, group 2 treated with DMBA (100 mg/kg, single dose) and group 3 receiving the DMBA and the aqueous extract at 100 mg/kg/d for 60 days. Results: Significant decrease in catalase (P<0.05), carbonic anhydrase (p <= 0.01), reduced glutathione (GSH) (P<0.01) and total protein (P<0.01) values was observed in the DMBA group compared with the healthy controls and DMBA + Plantago major groups. Conclusion: The results suggest preventive effects of Plantago major on DMBA induced oxidative damage in Wistar albino rats that might be due to decreased free radical generation.