A BIOCHEMICAL STUDY ON THE PROTECTIVE POTENTIAL OF Centaurium erythraea L. IN RATS AT ACUTE ASPIRIN EXPOSURE

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Özkol H., Tülüce Y., Koyuncu I., Balahoroglu R.

FRESENIUS ENVIRONMENTAL BULLETIN, cilt.20, ss.2699-2703, 2011 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20
  • Basım Tarihi: 2011
  • Dergi Adı: FRESENIUS ENVIRONMENTAL BULLETIN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2699-2703
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

https://www.researchgate.net/publication/286283285_A_biochemical_study_on_the_protective_potential_of_Centaurium_erythraea_L_in_rats_at_acute_aspirin_exposure


ABSTRACT

The aim of this study was to determine protective effect of Centaurium erythraea L. on rats exposed to aspirin (ASA). The protective influence of the 50% aqueous-ethanolic Centaurium erythraea L. extract (AECE) (100 mg/kg body weight) was investigated in rats exposed to a single dose of 200 mg/kg body weight ASA administration. Twenty-one Sprague-Dawley albino rats were distributed into three groups equally (n=7) as follows: A (control), B (only ASA-treated) and C (ASA+AECE-treated) group. At the end of 4 h ASA administration to groups B and C, some serum biochemical constituents were assigned and compared between the groups. Results showed that levels of aspartate aminotransferase, alanine aminotransferase, creatinine and potassium increased in group B compared with the control group, but they were decreased significantly with AECE supplementation. While lipase activity decreased only in group B, level of uric acid decreased both in groups B and C compared with control group. In conclusion, the current trial has shown that treatment of AECE with ASA supplied relative protection against acute ASA toxicity through ameliorating some blood parameters.