Functional role of crosslinking in alginate scaffold for drug delivery and tissue engineering: A review

Aguero L., Alpdagtas S., Ilhan E., Zaldivar-Silva D., GÜNDÜZ O.

EUROPEAN POLYMER JOURNAL, vol.160, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 160
  • Publication Date: 2021
  • Doi Number: 10.1016/j.eurpolymj.2021.110807
  • Journal Name: EUROPEAN POLYMER JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Chemical Abstracts Core, Communication Abstracts, INSPEC, Metadex, Civil Engineering Abstracts
  • Keywords: Alginate, Crosslinking, Wound healing, Drug delivery, Tissue engineering, Biocompatibility, IN-VITRO, PHOTOCROSSLINKED ALGINATE, BIOMEDICAL APPLICATIONS, MECHANICAL-PROPERTIES, SODIUM ALGINATE, BONE-FORMATION, HYDROGELS, CELL, DESIGN, VIVO
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

The actual tendency exhibits continuous increment to use alginate polysaccharides in drug delivery and tissue engineering fields due to its attractive properties. Alginate pH-sensitiveness and its fabrication techniques have been extensively reported in the literature. However, in this review, the essential role of crosslinking process in the scaffold design will be highlighted. We discuss the possibility to use a different type of crosslinking to create proper biomimetic alginate hydrogels, emphasizing the possibility to improve alginate mechanical properties through chemical modification by covalent crosslinking or ionic combination with other polymeric materials. At the same time, the relevance of the degradation process and biocompatibility in these applications is also detailed described.