The Protective Effect of Losartan on Diabetic Neuropathy in a Diabetic Rat Model


ÇAVUŞOĞLU T., KARADENIZ T., CAGILTAY E., KARADENIZ M., Yigitturk G., Acikgoz E., ...More

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, vol.123, no.8, pp.479-484, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 123 Issue: 8
  • Publication Date: 2015
  • Doi Number: 10.1055/s-0035-1550019
  • Journal Name: EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.479-484
  • Keywords: medicine, losartan, diabetes, electromyography, histopathological, NERVE GROWTH-FACTOR, ANGIOTENSIN-II, ACE-INHIBITOR, RISK-FACTORS, BLOOD-FLOW, LISINOPRIL, BLOCKADE, MECHANISMS, NEURONS, BDNF
  • Van Yüzüncü Yıl University Affiliated: No

Abstract

Aim: Involvement of the peripheral and autonomic nervous systems is possibly the most frequent complication of diabetes. Important risk factors included hyperglycemia, dyslipidemia, hypertension, and smoking. Angiotensin-converting-enzyme inhibitor (ACE) inhibitors should be beneficial in all vascular beds, including neuropathy and retinopathy. In this study we aimed to evaluate the effect of the angiotensin receptor blocker losartan on diabetic neuropathy in a diabetic rat model.