Akademik Veri Yönetim Sistemi
Southern Clinics of Istanbul Eurasia, cilt.35, sa.2, ss.191-195, 2024 (Hakemli Dergi)
Objective: There are numerous diagnostic, biological, and histological manifestations of
salivary gland tumors, each of which offers concerns and difficulties in terms of diagnosis,
grading, categorization, and therapy. The purpose of this study was to evaluate and compare
the immunohistochemical expression of Bcl-2, caspase-3, and GSTP in benign and malignant
salivary gland tumors, as well as how they are connected to a variety of clinicopathological
variables.
Methods: A total of 61 cases of buffered formalin-fixed, paraffin-embedded tissues from
previously identified cases of benign and malignant salivary gland tumors were included in
this study. The immunohistochemistry staining process was carried out according to the
manufacturer’s recommendations, employing polyclonal anti-Bcl-2, anti-caspase-3, and an-
ti-GST antibodies.
Results: The correlation between mean tumor diameter and Bcl-2 expression was shown
to be statistically significant (rs=0.258, p<0.05). In pleomorphic adenoma tumor tissues,
there were statistically significant correlations between the expression levels of Bcl-2 and
caspase-3 (rs=0.66, p<0.01), Bcl-2 and GST (rs=0.61, p<0.01), and caspase-3 and GST
(rs=0.73, p<0.01) when tumor types were compared. The tissues with pleomorphic ade-
noma, adenoid cystic carcinoma, and mucoepidermoid carcinoma had the highest staining
intensity of Bcl-2 expression, while the lowest staining intensity of GSTP expression was
observed.
Conclusion: It seems probable to draw the conclusion that salivary gland tumors that
resist apoptosis have elevated levels of Bcl-2 expression. The prognosis for salivary gland
tumors may be poor due to the positive correlation between tumor diameter and high Bcl-2
expression.