ASSESSMENT OF THE WHEATGRASS EFFECTS ON ANTIOXIDANT CAPACITY AND DNA DAMAGE IN RATS WITH EXPERIMENTAL RENAL FAILURE


Mis L. , COMBA B., Başbuğan Y. , Yasar S. , COMBA A.

FRESENIUS ENVIRONMENTAL BULLETIN, vol.28, no.4, pp.2876-2879, 2019 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 4
  • Publication Date: 2019
  • Title of Journal : FRESENIUS ENVIRONMENTAL BULLETIN
  • Page Numbers: pp.2876-2879
  • Keywords: Rat, TAS, TOS, Wheatgrass, Renal failure, OXIDATIVE STRESS, PATHOGENESIS, EXTRACT

Abstract

In this study, it was aimed to evaluate the effect of wheatgrass on antioxidant capacity and DNA damage in rats with renal failure. In the study, 200-300 g 24 healthy Wistar-Albino male rats obtained from YYU Experimental Animal Unit were used. The rats were randomly divided into 4 groups and each group was formed with 6 rats. Groups were allocated as; 1. Control Group, 2. Renal Failure Group (Genta Group) 3. Renal Failure + Wheatgrass Group (Genta +Wheatgrass) 4. Wheatgrass Group. Gentamicin sulfate was given intraperitoneal at a dose of 50 mg/kg for 1 week and once a day to the groups with renal failure (Groups 2 and 3). Wheat grass extract (10 ml/kg) was added to the drinking water of the wheatgrass group rats (3rd and 4th groups) once a day. This practice lasted for 4 weeks. Total oxidant, antioxidant quantities, DNA damage were evaluated at the end of 4 weeks. The result that wheatgrass could be useful in renal failure was reached.