Akademik Veri Yönetim Sistemi
New Frontiers in Health Sciences , Assoc. Prof. Onur ORAL,Assist Prof. Ali Kemal NALCI, Editör, Duvar Yayınları, İzmir, ss.143-159, 2023
The relationship between the gut and the skin, known as the gut-skin axis, plays a significant role in the development of psoriasis. The skin and gut are connected by a complex network of systems, including the crucial role played by microbiota. Patients with psoriasis have a weak gut barrier, so they are more likely to get diseases like irritable bowel syndrome that throw off their already delicate health balance. Researchers are working hard to find out what causes the gut barrier to break down in people with psoriasis and whether this could be a cause or effect of the disease. It has been proposed that the microbiota has a role in the pathophysiology of psoriasis. Despite tremendous breakthroughs in current biological therapy for psoriasis, there are still people who do not respond properly or who experience unpleasant consequences. The key to effective treatment should be personalized medicine. The goal of current scientific investigation is to find biomarkers that can forecast the emergence of negative side effects in psoriasis patients receiving biologic therapy. The aim of this section was to review the literature and determine the relationship between intestinal microbiota correlation with psoriasis and its pathophysiological process. We consider that the composition and activity of the gut microbiota may influence the efficacy and safety of the therapy and contribute also possible side effects.
Keywords: Psoriasis, microbiota, gut, skin, inflammation