Akademik Veri Yönetim Sistemi
Türkiye Klinikleri Oftalmoloji Dergisi, cilt.33, sa.1, ss.1-6, 2024 (Hakemli Dergi)
Objective: We aimed to evaluate the effectiveness and safety of Coenzyme Q10 (CoQ10) eye drops on corneal wound healing in bacterial keratitis. Material and Methods: Patients who were hos- pitalized and treated for bacterial keratitis were included in the study. The age, gender, and the affected eyes of the patients were recorded. The patients underwent a complete ophthalmologic examination and the presence or absence of hypopyon was recorded. The size of the corneal ulcer was measured horizontally and vertically. Patients were randomly divided into 2 groups. Both groups received topical antibi- otics and cyclopentolate drops. In addition to the first group, CoQ 10 eye drop 4×1 treatment was added. Corneal ulcer images were taken before the treatment and recorded daily after the treatment initiation, until the ulcer healed. Results: The mean age of the 32 patients in- cluded in the study was 51.16±25.31 (7-90) years, 20 (62.5%) were male and 12 (37.5%) were female. There was no statistically significant difference in terms of age, gender, right and left eye involvement, hy- popyon presence and corneal ulcer size in CoQ10 eye drop group (n=16) and control group (n=16) (p>0.05). The mean healing time was 12.25±6.02 days in CoQ10 eye drop group and 19±12.9 days in control group (p=0.076). Conclusion: The effect of CoQ 10 eye drops in the treatment of bacterial keratitis with corneal ulcers was not found to be statistically significant. However, it can be considered as an adjuvant agent in terms of shortening the healing time. There is a need for more extensive series, randomized, prospective clinical trials.