Investigation of the Reactions of New Pyrimidine Derivatives With Propargyl Bromide

Aykac A., Aslanoğlu F.

Journal of Heterocyclic Chemistry, 2026 (SCI-Expanded, Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2026
  • Doi Numarası: 10.1002/jhet.70202
  • Dergi Adı: Journal of Heterocyclic Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Chimica, EMBASE
  • Anahtar Kelimeler: propargyl bromide, thiazolo[3,2-a]pyrimidine-5-one, thioxo pyrimidine
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

Seven novel thioxo-pyrimidine derivatives not previously reported in the literature were synthesized via a Biginelli-type multicomponent reaction. These synthesized compounds were subsequently reacted with propargyl bromide under base-catalyzed conditions, yielding eight novel thiazolo[3,2-a]pyrimidine derivatives not previously described in the literature. In this step, the reaction conditions were optimized to improve the efficiency of the base-catalyzed transformation. The structures of all synthesized compounds were elucidated by 1H NMR, 13C NMR, and LC–MS/MS analyses.