Investigation of the Reactions of New Pyrimidine Derivatives With Propargyl Bromide
Journal of Heterocyclic Chemistry, cilt.63, sa.7, ss.1082-1088, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 63 Sayı: 7
- Basım Tarihi: 2026
- Doi Numarası: 10.1002/jhet.70202
- Dergi Adı: Journal of Heterocyclic Chemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Chimica, EMBASE
- Sayfa Sayıları: ss.1082-1088
- Anahtar Kelimeler: propargyl bromide, thiazolo[3,2-a]pyrimidine-5-one, thioxo pyrimidine
- Van Yüzüncü Yıl Üniversitesi Adresli: Evet
Özet
Seven novel thioxo-pyrimidine derivatives not previously reported in the literature were synthesized via a Biginelli-type multicomponent reaction. These synthesized compounds were subsequently reacted with propargyl bromide under base-catalyzed conditions, yielding eight novel thiazolo[3,2-a]pyrimidine derivatives not previously described in the literature. In this step, the reaction conditions were optimized to improve the efficiency of the base-catalyzed transformation. The structures of all synthesized compounds were elucidated by 1H NMR, 13C NMR, and LC–MS/MS analyses.