The Effects of Coriandrum sativum L. and Chaerophyllum macropodum Boiss. (Apiaceae) on human plasma angiotensin-converting enzyme (ACE) in vitro


Çelikezen F. Ç. , Türkoğlu V. , Fırat M. , Baş Z.

BEÜ Fen Bilimleri Dergisi, vol.10, no.7, pp.710-718, 2021 (International Refereed University Journal)

  • Publication Type: Article / Article
  • Volume: 10 Issue: 7
  • Publication Date: 2021
  • Title of Journal : BEÜ Fen Bilimleri Dergisi
  • Page Numbers: pp.710-718

Abstract

Hypertension is a very important problem around the world. The inhibition of the Angiotensin-converting enzyme

(ACE, EC.3.4.15.1.) is regarded as fundamental of hypertension treatment. However, synthetic ACE inhibitors

have several side effects. For this reason, there are lots of studies to improve green ACE inhibitors. Therefore, this

study was designed to determine the potential inhibitory effects of two members of Apiaceae, Coriandrum sativum

and Chaerophyllum macropodum, on human plasma ACE. For this purpose, water extracts of the plants were used.

ACE inhibition activity was detected spectrophotometrically. Both plant extracts showed an inhibitory effect on

ACE activity. The obtained results showed that Coriandrum sativum and Chaerophyllum macropodum have

inhibitory effects on human plasma ACE with an IC50 value of 0.7 mg/mL and 1.14 mg/mL, respectively.

Lineweaver-Burk graph was used to determine the inhibition type. The inhibition types were found as reversible

noncompetitive. According to the obtained results, Coriandrum sativum and Chaerophyllum macropodum are