BEÜ Fen Bilimleri Dergisi, vol.10, no.7, pp.710-718, 2021 (International Refereed University Journal)
Hypertension is a very important problem around the world. The inhibition of the Angiotensin-converting enzyme
(ACE, EC.18.104.22.168.) is regarded as fundamental of hypertension treatment. However, synthetic ACE inhibitors
have several side effects. For this reason, there are lots of studies to improve green ACE inhibitors. Therefore, this
study was designed to determine the potential inhibitory effects of two members of Apiaceae, Coriandrum sativum
and Chaerophyllum macropodum, on human plasma ACE. For this purpose, water extracts of the plants were used.
ACE inhibition activity was detected spectrophotometrically. Both plant extracts showed an inhibitory effect on
ACE activity. The obtained results showed that Coriandrum sativum and Chaerophyllum macropodum have
inhibitory effects on human plasma ACE with an IC50 value of 0.7 mg/mL and 1.14 mg/mL, respectively.
Lineweaver-Burk graph was used to determine the inhibition type. The inhibition types were found as reversible
noncompetitive. According to the obtained results, Coriandrum sativum and Chaerophyllum macropodum are