Akademik Veri Yönetim Sistemi
Cumhuriyet Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, cilt.9, sa.2, ss.221-226, 2024 (Hakemli Dergi)
Diabetes mellitus (DM) is a metabolic disease caused by irregularities in carbohydrate, fat and protein metabolism.
Today, it has been observed that alternative therapies are needed to control diabetes and reduce its complications.
In this study planned to investigate the anti-diabetic and antioxidant activity of Punica granatum seed oil, rats were
randomly selected with 8 rats in each group and divided equally into 4 groups. The control group received saline,
while the pomegranate oil group received pomegranate oil by gavage (2 ml/kg/day). To induce diabetes, 45 mg/kg
single dose of streptozotocin (STZ) i.p. was administered to the third and fourth group rats and STZ was administered
similarly to the fourth group rats and the same dose of pomegranate seed oil was given daily by gavage for three
weeks. At the end of the experiment, blood samples were taken from the hearts of the rats and glucose, insulin,
adiponectin, resistin, total cholesterol (TC), triglyceride (TG), HDL cholesterol, LDL-cholesterol, total antioxidant
status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) levels were recorded. In HDL and TAS levels,
an increasing effect was observed in the diabetes + pomegranate oil group. While there were no significant changes
in rescitin levels, adiponectin and insulin levels decreased significantly in the diabetic group. When the final body
weights were analyzed, it was determined that diabetic rats had the lowest value. Elevated glucose levels in diabetic
rats decreased significantly when pomegranate oil was added. It was concluded that pomegranate oil may have
antihyperglycemic, antioxidant and antihypercholesterolemic functions.
Keywords: Adiponectin, Antioxidant, Diabetes, Insulin, Pomegranate seed oil, Resistin