Electrooxidation of tetracycline antibiotic demeclocycline at unmodified boron-doped diamond electrode and its enhancement determination in surfactant-containing media


Allahverdiyeva S., Yardım Y. , Şentürk Z.

TALANTA, cilt.223, 2021 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

In this paper, for the first time, the study of voltammetric determination of tetracycline antibiotic demeclocycline was conducted. The oxidation of compound was investigated using a commercially available boron-doped diamond electrode pretreated electrochemically (anodic and subsequent cathodic). Addition of anionic surfactant, sodium dodecylsulfate (SDS) and cationic surfactant, cetyltrimethylammonium bromide (CTAB) to the demeclocycline-containing electrolyte solution at pH 2.0 and 9.0, respectively, was found to improve the sensitivity of the stripping voltammetric measurements. Employing square-wave stripping mode (after 30 s accumulation at open-circuit condition) in Britton-Robinson buffer, the limits of detection were found to be 1.17 mu g mL(-1) (2.3 x 10(-6) M) for 4 x 10(-4) SDS-containing buffer solution at pH 2, and 0.24 mu g mL(-1) (4.8 x 10(-7) M) for 1 x 10(-4) CTAB-containing buffer solution at pH 9.0. The feasibility of the developed approach for the quantification of demeclocycline was tested in urine samples.