The investigation of hawthorn (Crataegus orientalis) plant’s inhibition effect on angiotensin converting enzyme and in silico studies
NATURAL PRODUCT RESEARCH, cilt.1, sa.1, ss.1-17, 2024 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 1 Sayı: 1
- Basım Tarihi: 2024
- Doi Numarası: 10.1080/14786419.2024.2324467
- Dergi Adı: NATURAL PRODUCT RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA), Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, CINAHL, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.1-17
- Van Yüzüncü Yıl Üniversitesi Adresli: Evet
Özet
Hawthorn plant is used among people due to its cardiovascular,
anti-inflammatory, and antihistamine properties. But no scientific
study has been done about Crataegus orientalis (Mill.) M.Bieb. The
presented study was planned to determine the effects of ethanol
and n-hexane extracts of Crataegus orientalis leaves on human
plasma ACE enzyme. In the study, the effect of plant extracts on
ACE was studied by the spectrophotometric method. The chemical
composition of the plant extracts was determined by HPLC-DAD
analyses. In addition, molecular doking and ADME prediction studies
were carried out. As a result, the obtained data showed that
Crataegus orientalis could have an important place in the pharmaceutical
industry and drug discovery studies, as it supports the traditional
use of Crataegus orientalis as hypotensive. The results of
the molecular docking studies revealed that the interactions of the
selected compounds with the human ACE enzyme caused
inhibition.