The investigation of hawthorn (Crataegus orientalis) plant’s inhibition effect on angiotensin converting enzyme and in silico studies

Yavuz M., Çelikezen F. Ç., Fırat M., Baş Z., Türkoğlu V.

NATURAL PRODUCT RESEARCH, vol.1, no.1, pp.1-17, 2024 (SCI-Expanded)

  • Publication Type: Article / Article
  • Volume: 1 Issue: 1
  • Publication Date: 2024
  • Doi Number: 10.1080/14786419.2024.2324467
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA), Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, CINAHL, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.1-17
  • Van Yüzüncü Yıl University Affiliated: Yes


Hawthorn plant is used among people due to its cardiovascular,

anti-inflammatory, and antihistamine properties. But no scientific

study has been done about Crataegus orientalis (Mill.) M.Bieb. The

presented study was planned to determine the effects of ethanol

and n-hexane extracts of Crataegus orientalis leaves on human

plasma ACE enzyme. In the study, the effect of plant extracts on

ACE was studied by the spectrophotometric method. The chemical

composition of the plant extracts was determined by HPLC-DAD

analyses. In addition, molecular doking and ADME prediction studies

were carried out. As a result, the obtained data showed that

Crataegus orientalis could have an important place in the pharmaceutical

industry and drug discovery studies, as it supports the traditional

use of Crataegus orientalis as hypotensive. The results of

the molecular docking studies revealed that the interactions of the

selected compounds with the human ACE enzyme caused