Implications of obstructive sleep apnea on reproductive health: a study on anti-Mullerian hormone levels

Yıldız H., Alp H. H., Üçler R., Bilgin M. H.

Sleep and Breathing, 2024 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1007/s11325-024-02998-2
  • Dergi Adı: Sleep and Breathing
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, MEDLINE
  • Anahtar Kelimeler: AHI, Anti-mullerian hormone, Obstructive sleep apnea, Woman
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

Purpose: This study aimed to explore the association between anti-mullerian hormone (AMH) levels and obstructive sleep apnea (OSA) severity. Methods: A cross-sectional design was employed to evaluate AMH levels in 68 premenopausal women diagnosed with OSA at Van Yüzüncü Yıl University Faculty of Medicine. OSA severity was scored according to the 2018 AASM guidelines using a 16-channel Embla device. AMH levels were measured from blood samples using a commercially available kit. Results: The study found that AMH levels in OSA patients were significantly lower than those in the healthy control group. A statistically significant negative correlation between AMH and AHI levels was observed. When stratified by OSA severity, the lowest AMH levels were found in the severe OSA group. Conclusion: OSA may have potential endocrine implications, especially concerning reproductive health. Decreased AMH levels in OSA patients could indicate future risks of infertility or early menopause.