Topological Indices Study of Molecular Structure Hyaluronic Acid-Paclitaxel Conjugates in Cancer Treatment

Zhuang J., Shooshtari H., Cancan M.

Polycyclic Aromatic Compounds, vol.44, no.3, pp.1793-1804, 2024 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 3
  • Publication Date: 2024
  • Doi Number: 10.1080/10406638.2023.2207776
  • Journal Name: Polycyclic Aromatic Compounds
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Applied Science & Technology Source, CAB Abstracts, Chemical Abstracts Core, Communication Abstracts, Food Science & Technology Abstracts, Metadex, Pollution Abstracts, Veterinary Science Database, Civil Engineering Abstracts
  • Page Numbers: pp.1793-1804
  • Keywords: Cancer treatment, chemical graph, hyaluronic acid-paclitaxel conjugates
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

A large number of medical experiments have confirmed that the features of drugs have a close correlation with their molecular structure. Drug properties can be obtained by studying the molecular structure of corresponding drugs. The calculation of the topological index of a drug structure enables scientists to have a better understanding of the physical chemistry and biological characteristics of drugs. In this paper, we obtain the exact formulas by virtue of the edge-partition method for (Formula presented.) and (Formula presented.) By the appropriate choice of parameters (Formula presented.) and (Formula presented.) several new/old inequalities that reveal relationships between various topological indices are obtained. Our results remedy the lack of medicine experiments, thus providing a theoretical basis for pharmaceutical engineering.