This study has aimed to investigate the differences between the levels of trace elements in sheep with the diagnosis of ecthyma, and in healthy sheep. For this purpose, Be, Bi, Pb, Cd, Na, K, Ca, Mg, Fe, Cu, Zn, Se, Ni and Mn, Co, Cr, Li elements in the plasma of sheep with Contagious ecthyma detected with PCR and in sheep in the control group were analyzed with ICP-OES. In this study, the levels of Fe, Cu, Zn, Se and Pb trace elements were found to be statistically different between the sheep infected with parapoxvirus. The Na ele ment of the macro elements was observed to be statistically different in sheep with ecthyma, to the control group(P<0.05). When there are low levels of metal concentration in sheep with ecthyma, their immune system can be considered to be weakened. Further studies can be carried out on the increase in the risk of developing the disease as a result of, in particular, a decrease in the Fe, Cu, Zn and Se concentrations in sheep infected with the virus.