Akademik Veri Yönetim Sistemi
VI. INTERNATIONAL HEALTH, ENGINEERING AND SCIENCES CONGRESS , Van, Türkiye, 16 - 18 Haziran 2023, ss.35-36
This paper highlights the potential of N-Acetyl cysteine (NAC) in the treatment of neurological
diseases. NAC is the synthetic derivative of the endogenous amino acid L-site and is widely
used in treatments, thanks to its mucolytic property as a precursor of glutathione (GSH'). NAC
has attracted attention as a potential therapeutic agent in the treatment of neurological diseases
in recent years. NAC is of great importance because it provides neuroprotective effects by
reducing and neutralizing free radical damage in the brain. Oxidative stress is an important
factor in the pathogenesis of neurological diseases and causes cell damage, inflammation, and
neuronal degeneration. NAC acts as a precursor to a powerful antioxidant like GSH, helping to
reduce oxidative stress in the brain. NAC also plays an important role in regulating
neurotransmitters in the brain. It is particularly effective on glutamate and dopamine. Glutamate
is an important neurotransmitter for nerve transmission. Hypersecretion of glutamate can lead
to neurotoxicity and cell damage. NAC has a protective effect against the excessive release of
glutamate. Although NAC is widely used in the treatment of lung diseases, its role in
neurodegenerative diseases is not yet fully known. The antioxidant and anti-inflammatory
effects of NAC may shed light on important factors in the pathogenesis of neurological diseases.
Neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease occur as a
result of neuronal losses, inflammation, and oxidative stress. In addition, NAC has a potential
role in the treatment of psychiatric disorders. For example, diseases such as schizophrenia and
bipolar disorder are associated with dopamine and glutamate dysregulation. By regulating the
dopaminergic and glutamate systems, NAC may alleviate the symptoms of these diseases and
contribute to the treatment. The anti-inflammatory effects of NAC are also effective in reducing
inflammation, which plays an important role in the pathogenesis of many neurological diseases.
For example, conditions such as multiple sclerosis, ALS, and neurological diseases due to
infections are associated with inflammation. NAC can affect the course of these diseases by
suppressing inflammation. Considering the reparative role and anti-inflammatory role of NAC
in the blood and brain barrier, we think that it will be evaluated in detail in experimental studies
with combined therapies, which can make important contributions to the literature. However, it
needs to be supported by more clinical and experimental studies.
Keywords: Glutathione, Oxidative Stress, N Acetyl Cysteine, Neurodegenerative Diseases