Synthesis of 1,3‐oxazepine derivatives via tandem reaction of 5‐benzylidine Meldrum's acids with TosMIC in presence of potassium carbonate

Aslanoğlu F.

JOURNAL OF HETEROCYCLIC CHEMISTRY, cilt.8, ss.1364-1368, 2024 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1002/jhet.4860
  • Dergi Adı: JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), Chemical Abstracts Core, Chimica
  • Sayfa Sayıları: ss.1364-1368
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

A new and efficient method for synthesizing 1,3-oxazepines has been developed. The synthetic strategy of this method is based initially on the Knoevenagel reaction to form 5-benzylidine Meldrum's acid, followed by a 7-endo-cyclization reaction with TosMIC (p-toluenesulfonylmethyl isocyanide) in the presence of base. In the optimization studies carried out on this tandem reaction, the highest yield was obtained when K2CO3 was used as the base.