Large-scale evaluation of dynamically important residues in proteins predicted by the perturbation analysis of a coarse-grained elastic model

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ZHENG W., Tekpinar M.

BMC STRUCTURAL BIOLOGY, cilt.9, 2009 (SCI-Expanded) identifier identifier identifier

Özet

Backgrounds: It is increasingly recognized that protein functions often require intricate conformational dynamics, which involves a network of key amino acid residues that couple spatially separated functional sites. Tremendous efforts have been made to identify these key residues by experimental and computational means.