The Role of Insulin Receptor Substrate Proteins in Bronchopulmonary Dysplasia and Asthma: New Potential Perspectives

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Görgişen G., Aydin M., Mboma O., Goekyildirim M. Y., Chao C.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, cilt.23, sa.17, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 23 Sayı: 17
  • Basım Tarihi: 2022
  • Doi Numarası: 10.3390/ijms231710113
  • Dergi Adı: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Anahtar Kelimeler: insulin receptor substrates, asthma, bronchopulmonary dysplasia, pediatric lung disease, GROWTH-FACTOR-I, PROLONGED MECHANICAL VENTILATION, INDUCED PULMONARY-FIBROSIS, NF-KAPPA-B, IRS PROTEINS, TYROSINE PHOSPHORYLATION, SIGNALING PATHWAYS, MAMMALIAN TARGET, LUNG INJURY, CROSS-TALK
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

Insulin receptor substrates (IRSs) are proteins that are involved in signaling through the insulin receptor (IR) and insulin-like growth factor (IGFR). They can also interact with other receptors including growth factor receptors. Thus, they represent a critical node for the transduction and regulation of multiple signaling pathways in response to extracellular stimuli. In addition, IRSs play a central role in processes such as inflammation, growth, metabolism, and proliferation. Previous studies have highlighted the role of IRS proteins in lung diseases, in particular asthma. Further, the members of the IRS family are the common proteins of the insulin growth factor signaling cascade involved in lung development and disrupted in bronchopulmonary dysplasia (BPD). However, there is no study focusing on the relationship between IRS proteins and BPD yet. Unfortunately, there is still a significant gap in knowledge in this field. Thus, in this review, we aimed to summarize the current knowledge with the major goal of exploring the possible roles of IRS in BPD and asthma to foster new perspectives for further investigations.