Analgesic and hepatotoxic effects of Ononis spinosa

Yilmaz B. S. , Ozbek H., Citoglu G. S. , Ugras S., Bayram I. , Erdogan E.

PHYTOTHERAPY RESEARCH, vol.20, no.6, pp.500-503, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 6
  • Publication Date: 2006
  • Doi Number: 10.1002/ptr.1891
  • Title of Journal : PHYTOTHERAPY RESEARCH
  • Page Numbers: pp.500-503


The present study investigated the analgesic and hepatoprotective activities of a water extract of Ononis spinosa L. (OS) in mice. Analgesic activity was based on the pain thresholds measured with the tail-flick test before administration at 30, 90 and 150 min. The results were analysed with one-way variance analysis. The extract of Ononis spinosa showed analgesic activity equivalent to aspirin at 30 and 90 min and even higher than aspirin with the 50 mg/kg dose. At a dose of 100 mg/kg OS showed an analgesic effect equivalent to aspirin at all time points.