Congenital extraneural hemangioblastoma in a lamb

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Yaman T., Karasu A., UYAR A., Kuşçu Y., Keleş Ö. F.

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, vol.31, no.2, pp.263-266, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 2
  • Publication Date: 2019
  • Doi Number: 10.1177/1040638719830464
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.263-266
  • Keywords: CD45, glial fibrillary acidic protein, hemangioblastoma, lambs, neuron-specific enolase, TUMOR-LIKE LESIONS, DOMESTIC-ANIMALS, HEMANGIOMAS
  • Van Yüzüncü Yıl University Affiliated: Yes


A 1-mo-old Ivesi male lamb was presented with 2 large red masses on the skin of the left ear. The tumors were removed using gentle dissection and submitted for histologic evaluation. The tumors consisted of numerous thin-walled capillaries lined by endothelial cells and nests of stromal cells. Immunohistochemically, the endothelial cells were positive for CD45, and the stromal cells were positive for neuron-specific enolase. GFAP-positive cells were occasionally present within the tumor. Endothelial and stromal cells were negative for S100, CD34, CD31, and factor VIII-related antigen. The tumor had strong gross, microscopic, and immunohistochemical similarities with human extraneural hemangioblastoma.