Direct sulfonamidation of (hetero)aromatic C-H bonds with sulfonyl azides: a novel and efficient route toN-(hetero)aryl sulfonamides

Liu Z., Ebadi A., Toughani M., Mert N., Vessally E.

RSC ADVANCES, vol.10, no.61, pp.37299-37313, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 10 Issue: 61
  • Publication Date: 2020
  • Doi Number: 10.1039/d0ra04255b
  • Journal Name: RSC ADVANCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, Compendex, Metadex, Directory of Open Access Journals
  • Page Numbers: pp.37299-37313
  • Van Yüzüncü Yıl University Affiliated: Yes


N-Aryl sulfonamides belong to a highly important class of organosulfur compounds which are found in a number of FDA-approved drugs such as dofetilide, dronedarone, ibutilide, sotalol, sulfadiazine, sulfamethizole, vemurafenib, and many more. There is therefore continuing interest in the development of novel and convenient protocols for the preparation of these pharmaceutically important compounds. Recently, direct sulfonamidation of (hetero)aromatic C-H bonds with easily available sulfonyl azides has emerged as an attractive and powerful strategy to accessN-(hetero)aryl sulfonamides where non-toxic nitrogen gas forms as the sole by-product. This review highlights recent advances and developments (2012-2020) in this fast growing research area with emphasis on the mechanistic features of the reactions.