Direct sulfonamidation of (hetero)aromatic C-H bonds with sulfonyl azides: a novel and efficient route toN-(hetero)aryl sulfonamides

Liu Z., Ebadi A., Toughani M., Mert N., Vessally E.

RSC ADVANCES, cilt.10, sa.61, ss.37299-37313, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 10 Sayı: 61
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1039/d0ra04255b
  • Dergi Adı: RSC ADVANCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, Compendex, Metadex, Directory of Open Access Journals
  • Sayfa Sayıları: ss.37299-37313
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

N-Aryl sulfonamides belong to a highly important class of organosulfur compounds which are found in a number of FDA-approved drugs such as dofetilide, dronedarone, ibutilide, sotalol, sulfadiazine, sulfamethizole, vemurafenib, and many more. There is therefore continuing interest in the development of novel and convenient protocols for the preparation of these pharmaceutically important compounds. Recently, direct sulfonamidation of (hetero)aromatic C-H bonds with easily available sulfonyl azides has emerged as an attractive and powerful strategy to accessN-(hetero)aryl sulfonamides where non-toxic nitrogen gas forms as the sole by-product. This review highlights recent advances and developments (2012-2020) in this fast growing research area with emphasis on the mechanistic features of the reactions.