Decreased Fibulin-3 Levels in Esophageal Squamous Cell Carcinoma
Eastern Journal of Medicine, cilt.31, sa.3, ss.556-560, 2026 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 31 Sayı: 3
- Basım Tarihi: 2026
- Doi Numarası: 10.5505/ejm.2026.40504
- Dergi Adı: Eastern Journal of Medicine
- Derginin Tarandığı İndeksler: Scopus, EMBASE, TR DİZİN (ULAKBİM), Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest), Pharma Collection (ProQuest)
- Sayfa Sayıları: ss.556-560
- Anahtar Kelimeler: decreased levels, early detection, Esophageal squamous cell carcinoma, fibulin-3, tumor biomarker
- Van Yüzüncü Yıl Üniversitesi Adresli: Evet
Özet
Esophageal squamous cell carcinoma (ESCC) remains a significant global health burden, highlighting the need to identify novel tumor biomarkers for early diagnosis and prognosis. The objective of this study was to investigate preoperative serum Fibulin-3 levels in patients with ESCC and to compare these levels with those of healthy individuals in order to assess the potential of Fibulin-3 as a diagnostic biomarker for ESCC. A total of 70 patients (mean age, 56.7 years; 57.1% males) with ESCC and 50 controls (mean age, 55.9 years; 54.0% males) were included. Serum samples were collect ed preoperatively and analyzed for Fibulin-3 levels using a commercially available sandwich enzyme-linked immunosorbent assay kit (Biocompare, USA). Preoperative serum Fibulin-3 levels were found to be significantly lower in patients with ESCC (mean, 35.9 1 ng/mL; range, 10-73 ng/mL) compared with the control group (mean, 96.61 ng/mL, range, 57-168 ng/mL) (p < 0.001). To the best of our knowledge, this was the first study to report a significant reduction in serum Fibulin-3 levels in patients with ESCC. These findings suggested that Fibulin-3 may serve as a potential biomarker for ESCC detection. Further large-scale studies were warranted to clarify its clinical relevance and underlying molecular mechanisms in ESCC pathogenesis.