Investigation of DNA-Binding Activities of Zinc(II) and Cobalt(II) Phthalocyanine Compounds with 3,4,5-Trimethoxybenzyloxy Substituents
CHEMISTRYSELECT, cilt.2, sa.35, ss.11659-11665, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 2 Sayı: 35
- Basım Tarihi: 2017
- Doi Numarası: 10.1002/slct.201702362
- Dergi Adı: CHEMISTRYSELECT
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.11659-11665
- Anahtar Kelimeler: Calf Thymus-DANN, DNA binding, Phthalocyanine compounds, UV-Vis spectroscopy, TRANSITION-METAL-COMPLEXES, TOPOISOMERASE-I INHIBITION, CALF THYMUS DNA, SCHIFF-BASE, PHOTODYNAMIC THERAPY, CYTOTOXIC ACTIVITY, MOLECULAR DOCKING, CLEAVAGE, ACID, BEHAVIOR
- Van Yüzüncü Yıl Üniversitesi Adresli: Evet
Özet
In this study, DNA-binding activities of previously synthesized tetrakis(3,4,5-trimethoxybenzyloxy)-substituted Zn(II) and Co(II) phthalocyanines (Pc4 and Pc5) have been chosen for the study. The interaction of synthesized tetrakis(3,4,5-trimethoxybenzyloxy)-substituted Zn(II) and Co(II) phthalocyanine compounds with CT-DNA was investigated by using UV/Vis titrimetric method, fluorescence spectroscopy, cyclic voltammetry, thermal denaturation profile, gel electrophoresis and viscosty measurement in a Tris-HCI buffer at pH 7.0. The results indicated that tetrakis(3,4,5-trimethoxybenzyloxy)-substituted Zn(II) and Co(II) phthalocyanines (Pc4 and Pc5) can interact with CT-DNA via intercalation binding mode.