Investigation of DNA-Binding Activities of Zinc(II) and Cobalt(II) Phthalocyanine Compounds with 3,4,5-Trimethoxybenzyloxy Substituents

ARSLANTAŞ A., Ağırtaş M. S.

CHEMISTRYSELECT, cilt.2, sa.35, ss.11659-11665, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 2 Sayı: 35
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1002/slct.201702362
  • Dergi Adı: CHEMISTRYSELECT
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.11659-11665
  • Anahtar Kelimeler: Calf Thymus-DANN, DNA binding, Phthalocyanine compounds, UV-Vis spectroscopy, TRANSITION-METAL-COMPLEXES, TOPOISOMERASE-I INHIBITION, CALF THYMUS DNA, SCHIFF-BASE, PHOTODYNAMIC THERAPY, CYTOTOXIC ACTIVITY, MOLECULAR DOCKING, CLEAVAGE, ACID, BEHAVIOR
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

In this study, DNA-binding activities of previously synthesized tetrakis(3,4,5-trimethoxybenzyloxy)-substituted Zn(II) and Co(II) phthalocyanines (Pc4 and Pc5) have been chosen for the study. The interaction of synthesized tetrakis(3,4,5-trimethoxybenzyloxy)-substituted Zn(II) and Co(II) phthalocyanine compounds with CT-DNA was investigated by using UV/Vis titrimetric method, fluorescence spectroscopy, cyclic voltammetry, thermal denaturation profile, gel electrophoresis and viscosty measurement in a Tris-HCI buffer at pH 7.0. The results indicated that tetrakis(3,4,5-trimethoxybenzyloxy)-substituted Zn(II) and Co(II) phthalocyanines (Pc4 and Pc5) can interact with CT-DNA via intercalation binding mode.