Investigation of DNA-Binding Activities of Zinc(II) and Cobalt(II) Phthalocyanine Compounds with 3,4,5-Trimethoxybenzyloxy Substituents


ARSLANTAŞ A., Ağırtaş M. S.

CHEMISTRYSELECT, vol.2, no.35, pp.11659-11665, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 2 Issue: 35
  • Publication Date: 2017
  • Doi Number: 10.1002/slct.201702362
  • Journal Name: CHEMISTRYSELECT
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.11659-11665
  • Keywords: Calf Thymus-DANN, DNA binding, Phthalocyanine compounds, UV-Vis spectroscopy, TRANSITION-METAL-COMPLEXES, TOPOISOMERASE-I INHIBITION, CALF THYMUS DNA, SCHIFF-BASE, PHOTODYNAMIC THERAPY, CYTOTOXIC ACTIVITY, MOLECULAR DOCKING, CLEAVAGE, ACID, BEHAVIOR
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

In this study, DNA-binding activities of previously synthesized tetrakis(3,4,5-trimethoxybenzyloxy)-substituted Zn(II) and Co(II) phthalocyanines (Pc4 and Pc5) have been chosen for the study. The interaction of synthesized tetrakis(3,4,5-trimethoxybenzyloxy)-substituted Zn(II) and Co(II) phthalocyanine compounds with CT-DNA was investigated by using UV/Vis titrimetric method, fluorescence spectroscopy, cyclic voltammetry, thermal denaturation profile, gel electrophoresis and viscosty measurement in a Tris-HCI buffer at pH 7.0. The results indicated that tetrakis(3,4,5-trimethoxybenzyloxy)-substituted Zn(II) and Co(II) phthalocyanines (Pc4 and Pc5) can interact with CT-DNA via intercalation binding mode.