Kahramanmaraş Sütçü İmam Üniversitesi Fen ve Mühendislik Dergisi, vol.26, no.6, pp.1221-1229, 2023 (Peer-Reviewed Journal)
Since synthetic drugs cause many side effects and have a high cost,
there has been increasing interest in the development of herbalbased
drugs that have fewer side effects and are relatively
inexpensive. Capparis sicula is traditionally used in the treatment of
some diseases among people. For this purpose, the antioxidant and
antimicrobial properties of the methanol extract of the Capparis
sicula plant and its inhibitory effects on COX-1 and COX-2 enzymes
were investigated. In the study, the antioxidant properties of the
Capparis sicula plant were determined by DPPH and CUPRAC
methods, while its antimicrobial properties were determined by the
disk diffusion method. The effect of Capparis sicula on COX-1 and
COX-2 enzymes was determined colorimetrically using commercial
kits. The results showed that Capparis sicula had a significant
antioxidant effect, but did not have any antimicrobial effect on
standard strains of Staphylococcus aureus, Pseudomonas
aeruginosa, Escherichia coli and Candida albicans. In addition, the
inhibitory effect on the COX-1 enzyme was 4.23% for the first time,
and the inhibition effect on the COX-2 enzyme was determined as
23.21%. As a result, the pharmaceutical, food and cosmetic
industries can use Capparis sicula as an important source of natural
raw materials.