Determination of in Vitro Antioxidant, Antimicrobial Properties and COX-1/COX-2 Enzyme Inhibition Activity of Capparis Sicula

Acar N., Çelikezen F. Ç., Şahin I. H., Fırat M., Koçyiği R., Kireçci O. A.

Kahramanmaraş Sütçü İmam Üniversitesi Fen ve Mühendislik Dergisi, cilt.26, sa.6, ss.1221-1229, 2023 (Hakemli Dergi)

Özet

Since synthetic drugs cause many side effects and have a high cost,

there has been increasing interest in the development of herbalbased

drugs that have fewer side effects and are relatively

inexpensive. Capparis sicula is traditionally used in the treatment of

some diseases among people. For this purpose, the antioxidant and

antimicrobial properties of the methanol extract of the Capparis

sicula plant and its inhibitory effects on COX-1 and COX-2 enzymes

were investigated. In the study, the antioxidant properties of the

Capparis sicula plant were determined by DPPH and CUPRAC

methods, while its antimicrobial properties were determined by the

disk diffusion method. The effect of Capparis sicula on COX-1 and

COX-2 enzymes was determined colorimetrically using commercial

kits. The results showed that Capparis sicula had a significant

antioxidant effect, but did not have any antimicrobial effect on

standard strains of Staphylococcus aureus, Pseudomonas

aeruginosa, Escherichia coli and Candida albicans. In addition, the

inhibitory effect on the COX-1 enzyme was 4.23% for the first time,

and the inhibition effect on the COX-2 enzyme was determined as

23.21%. As a result, the pharmaceutical, food and cosmetic

industries can use Capparis sicula as an important source of natural

raw materials.