Strontium ranelate treatment improves oxidative damage in osteoporotic rat model


Yalin S., Sagir O., Comelekoglu U., Berkoz M. , Eroglu P.

PHARMACOLOGICAL REPORTS, vol.64, no.2, pp.396-402, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 64 Issue: 2
  • Publication Date: 2012
  • Doi Number: 10.1016/s1734-1140(12)70780-6
  • Title of Journal : PHARMACOLOGICAL REPORTS
  • Page Numbers: pp.396-402
  • Keywords: strontium ranelate, osteoporosis, oxidative stress, ovariectomy, rat, LIPID-PEROXIDATION, PINEALECTOMIZED RATS, ANTIOXIDANT ENZYMES, BONE-FORMATION, PROGESTERONE, ESTRADIOL, STRESS, SYSTEM, WOMEN, ASSAY

Abstract

Background: Osteoporosis is the most common skeletal disorder and is considered a risk of fracture. Most medication used for the treatment of osteoporosis is antiresorptive; however, strontium ranelate (Sr) therapy in postmenopausal women has shown a double effect on resorption and bone formation. In this study, the effect of Sr on status of the oxidative stress and antioxidant defence system was investigated.