PHARMACOLOGICAL REPORTS, vol.64, no.2, pp.396-402, 2012 (Journal Indexed in SCI)
Article / Article
Title of Journal :
strontium ranelate, osteoporosis, oxidative stress, ovariectomy, rat, LIPID-PEROXIDATION, PINEALECTOMIZED RATS, ANTIOXIDANT ENZYMES, BONE-FORMATION, PROGESTERONE, ESTRADIOL, STRESS, SYSTEM, WOMEN, ASSAY
Background: Osteoporosis is the most common skeletal disorder and is considered a risk of fracture. Most medication used for the treatment of osteoporosis is antiresorptive; however, strontium ranelate (Sr) therapy in postmenopausal women has shown a double effect on resorption and bone formation. In this study, the effect of Sr on status of the oxidative stress and antioxidant defence system was investigated.