Strontium ranelate treatment improves oxidative damage in osteoporotic rat model
PHARMACOLOGICAL REPORTS, cilt.64, sa.2, ss.396-402, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 64 Sayı: 2
- Basım Tarihi: 2012
- Doi Numarası: 10.1016/s1734-1140(12)70780-6
- Dergi Adı: PHARMACOLOGICAL REPORTS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.396-402
- Anahtar Kelimeler: strontium ranelate, osteoporosis, oxidative stress, ovariectomy, rat, LIPID-PEROXIDATION, PINEALECTOMIZED RATS, ANTIOXIDANT ENZYMES, BONE-FORMATION, PROGESTERONE, ESTRADIOL, STRESS, SYSTEM, WOMEN, ASSAY
- Van Yüzüncü Yıl Üniversitesi Adresli: Hayır
Özet
Background: Osteoporosis is the most common skeletal disorder and is considered a risk of fracture. Most medication used for the treatment of osteoporosis is antiresorptive; however, strontium ranelate (Sr) therapy in postmenopausal women has shown a double effect on resorption and bone formation. In this study, the effect of Sr on status of the oxidative stress and antioxidant defence system was investigated.