Pharmacokinetics and tissue levels of tilmicosin in fowls

Keles O., Bakirel T., Sener S., Baktir G., Dagoglu G., Ozkan O.

TURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCES, vol.25, no.4, pp.629-634, 2001 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 4
  • Publication Date: 2001
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.629-634
  • Van Yüzüncü Yıl University Affiliated: No


Tilmicosin is a long-acting macrolide antibiotic used in the treatment of respiratory disease. It was administered once (SO mg/kg b.wt) to fowls via the oral route for determination of kinetic properties and tissue levels. After oral administration, tilmicosin's pharmacokinetics conformed to a two compartment open model. Tilmicosin was slowly eliminated from the serum and lung with mean half-lives of 30.18 +/- 2.38 and 75.74 +/- 3.67 hours, respectively The mean maximum concentration of the drug in the lungs was found to be 6.2 times greater that of serum. Serum and lung tilmicosin concentrations reached peak Values 4.66 +/- 2 and 17.78 +/- 7.51 hours, respectively, after oral administration. In fowls, the apparent volume of distribution was found to be more than 1 L/kg, indicating extensive tissue distribution. The clearance Values were calculated to be 1.33 +/- 0.06 for serum and 0.11 +/- 0.004 Vh for lung.