Use of pyridoxine and pyridostigmine in children with vincristine-induced neuropathy

AKBAYRAM S., AKGUN C., Dogan M., SAYIN R., ÇAKSEN H., Oner A. F.

INDIAN JOURNAL OF PEDIATRICS, cilt.77, sa.6, ss.681-683, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 77 Sayı: 6
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1007/s12098-010-0096-z
  • Dergi Adı: INDIAN JOURNAL OF PEDIATRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.681-683
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

Four children with vincristine (VCR)-induced neuropathy are being reported. All cases were followed with the diagnosis of acute lymphoblastic leukemia. Two were boys aged between 2 and 13 year. Electromyographic examination consisted of sensoriomotor polyneuropathy with axonal involvement in three patients. In another patient, it consisted of motor axonal polyneuropathy. In all patients, pyridoxine and pyridostigmine were successfully used in the treatment of VCR-induced neuropathy. They recovered completely with this drug combination. Recovering period of symptoms was between 1-2 week.