Use of pyridoxine and pyridostigmine in children with vincristine-induced neuropathy

AKBAYRAM S., AKGUN C., Dogan M., SAYIN R., ÇAKSEN H., Oner A. F.

INDIAN JOURNAL OF PEDIATRICS, vol.77, no.6, pp.681-683, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 77 Issue: 6
  • Publication Date: 2010
  • Doi Number: 10.1007/s12098-010-0096-z
  • Journal Name: INDIAN JOURNAL OF PEDIATRICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.681-683
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

Four children with vincristine (VCR)-induced neuropathy are being reported. All cases were followed with the diagnosis of acute lymphoblastic leukemia. Two were boys aged between 2 and 13 year. Electromyographic examination consisted of sensoriomotor polyneuropathy with axonal involvement in three patients. In another patient, it consisted of motor axonal polyneuropathy. In all patients, pyridoxine and pyridostigmine were successfully used in the treatment of VCR-induced neuropathy. They recovered completely with this drug combination. Recovering period of symptoms was between 1-2 week.