Synthesis, Physicochemical Characterization and Biological Evaluation of Sweet Almond Oil-and Juniper Oil-Derived Organo-particles
Journal of Research in Pharmacy, cilt.30, sa.4, ss.1027-1044, 2026 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 30 Sayı: 4
- Basım Tarihi: 2026
- Doi Numarası: 10.12991/jrespharm.1721538
- Dergi Adı: Journal of Research in Pharmacy
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.1027-1044
- Anahtar Kelimeler: CAPAN-1-4, Juniper oil-3, L-929-5, Organo-particle-1, Sweet Almond oil-2
- Van Yüzüncü Yıl Üniversitesi Adresli: Evet
Özet
In this study, p(SAO) and p(JO) organo-particles were synthesized from sweet almond oil and juniper oil via a redox polymerization method to investigate their physicochemical properties and in vitro biological activities, including antioxidant, antimicrobial, hemocompatibility, and cytotoxic effects. The structural and functional characteristics of the synthesized organo-particles were analyzed using Fourier Transform Infrared Spectroscopy (FT-IR). Particle size distribution, zeta potential, and polydispersity index were determined by dynamic light scattering (DLS), while morphological features were examined using scanning electron microscopy (SEM). The bioactivity of the organo-particles was evaluated through antioxidant, antimicrobial, and biocompatibility assays. In vitro cytotoxicity was assessed using the MTT assay on L-929 fibroblasts and Capan-1 pancreatic cancer cell lines. The results demonstrated that both p(SAO) and p(JO) increased cell viability in L-929 fibroblast cells, indicating good cytocompatibility. In contrast, p(JO) exhibited a more pronounced cytotoxic effect against Capan-1 pancreatic cancer cells, with activity comparable to doxorubicin. Moreover, combined treatment of p(JO) with doxorubicin further enhanced cytotoxic efficiency, suggesting a potential sensitizing or synergistic effect. Overall, the findings indicate that p(SAO) and particularly p(JO) organo-particles possess promising multifunctional bioactivities, including selective in vitro anticancer potential, while maintaining compatibility with normal fibroblast cells. These results suggest that p(JO) may serve as a potential candidate for further biomedical and anticancer-related investigations, pending validation through in vivo and mechanistic studies.