A topological index (TI) is a positive real number associated with the graph of molecule and remains invariant up to graph isomorphism. Until now, several TIs are defined and there are mainly three types: Degree depending, distance depending and spectrum depending. All these TIs found huge applications in pharmacy, theoretical chemistry and especially in QSPR/QSAR research. The aim of our study was to compute degree depending TIs for Hex board graph and its line graph. We firstly computed M-polynomial and by applying calculus, we computed several degree-based topological indices of Hex board graph and its line graph.