Anakinra and Myocardial Injury After Cardiac Arrest in Rats
Eastern Journal of Medicine, cilt.31, sa.3, ss.527-533, 2026 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 31 Sayı: 3
- Basım Tarihi: 2026
- Doi Numarası: 10.5505/ejm.2026.62592
- Dergi Adı: Eastern Journal of Medicine
- Derginin Tarandığı İndeksler: Scopus, EMBASE, TR DİZİN (ULAKBİM), Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest), Pharma Collection (ProQuest)
- Sayfa Sayıları: ss.527-533
- Anahtar Kelimeler: Anakinra, cardiac arrest, cardiopulmonary resuscitation, interleukin-1, myocardial injury, rat
- Van Yüzüncü Yıl Üniversitesi Adresli: Evet
Özet
Post-cardiac arrest myocardial injury is an important component of post-cardiac arrest syndrome and is associated with global ischemia-reperfusion, endothelial dysfunction, oxidative stress, and inflammatory activation. Interleukin-1 blockade may modulate ischemia-reperfusion injury; however, its histopathological effects on myocardial tissue after cardiac arrest remain unclear. This study aimed to evaluate the effect s of anakinra on early myocardial histopathological changes in a rat model of asphyxia-induced cardiac arrest and cardiopulmonary resuscitation. Twenty-four male Wistar Albino rats were randomly divided into three groups: control, sham, and anakinra groups, with eight rats in each group. Cardiac arrest and cardiopulmonary resuscitation were performed in the sham and anakinra groups. After resuscitation, the sham group received intraperitoneal 0.9% NaCl, whereas the anakinra group received intraperitoneal anakinra at a dose of 50 mg/kg. Cardiac tissues were collected at the sixth minute after intervention and examined histopathologically. Myocardial fiber disorganization, interstitial edema, congestion, and polymorphonuclear leukocyte infiltration were graded semi-quantitatively. Myocardial fiber disorganization, interstitial edema, and congestion differed significantly among the groups. Compared with the sham group, anakinra significantly reduced myocardial congestion scores (p = 0.015). However, it did not significantly improve myocardial fiber disorganization or interstitial edema. Polymorphonuclear leukocyte infiltration was not observed at the early post-resuscitation time point examined in any group. Anakinra significantly attenuated myocardial congestion in the early period after asphyxia-induced cardiac arrest and resuscitation, suggesting a selective effect on the microvascular component of post-resuscitation myocardial injury.