Synthesis of Novel Benzothiophene Derivatives via Cyclization Reactions
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, vol.56, no.7, pp.1272-1278, 2020 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 56 Issue: 7
- Publication Date: 2020
- Doi Number: 10.1134/s1070428020070222
- Journal Name: RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier
- Page Numbers: pp.1272-1278
- Van Yüzüncü Yıl University Affiliated: Yes
Abstract
The Sonogashira cross coupling reaction of 2-bromo-5-(4-methoxyphenyl)thiophene and 1-ethynyl-2-(methylsulfanyl)benzene gave 2-(4-methoxyphenyl)-5-{[2-(methylsulfanyl)phenyl]ethynyl}thiophene which was subjected to electrophilic cyclization by the action of iodine to obtain 3-iodo-2-[5-(4-methoxyphenyl)thiophen-2-yl]-1-benzothiophene. Stille and Sonogashira coupling reactions of the latter afforded a series of new 3-substituted 2-[5-(4-methoxyphenyl)thiophen-2-yl]-1-benzothiophene derivatives of potential pharmacological interest.