The Influence of Organic Vanadium Complexes on an Antioxidant Profile in Adipose Tissue in Wistar Rats

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Francik R., Kryczyk-Koziol J., Krosniak M., Francik S., Hebda T., Pedryc N., ...Daha Fazla

MATERIALS, cilt.15, sa.5, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 5
  • Basım Tarihi: 2022
  • Doi Numarası: 10.3390/ma15051952
  • Dergi Adı: MATERIALS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, CAB Abstracts, Communication Abstracts, Compendex, INSPEC, Metadex, Veterinary Science Database, Directory of Open Access Journals, Civil Engineering Abstracts
  • Anahtar Kelimeler: organic vanadium complexes, adipose tissue, antioxidants, high-fat diet, metabolic rate, OXIDATIVE STRESS, HIGH-FAT, INSULIN-RESISTANCE, IN-VITRO, OBESITY, INFLAMMATION, ELEMENT, HYPERGLYCEMIA, ADIPOGENESIS, EXPRESSION
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

One of the aspects of biological activity of vanadium is its influence on carbohydrate metabolism. For more than 30 years, various vanadium complexes have been tested as antidiabetic agents. This study researched organic vanadium complexes with bipyridinium ligands and their influences on metabolic rate, as well as on the antioxidant activity of adipose tissue. The effects of sodium (2,2 '-bipyridine) oxidobisperoxovanadate (V) octahydrate (known as the V complex), bis(2,2 '-bipyridine) oxidovanadium (IV) sulfate dehydrate (known as the B complex), and bis(4.4 '-dimethyl-2,2 '-bipyridine) oxidovanadium (IV) sulfate dihydrate (labelled as the BM complex) were assessed. Solutions of the tested complexes were introduced intraperitoneally with a probe to animals fed with either a control diet or a high-fat diet. The BM complex had a significant influence on the increase in ferric reducing antioxidant power, as well as on the concentration of glutathione in the adipose tissue of rats fed with a high-fat diet. The V complex increased the concentration of glutathione in the adipose tissue of rats fed with control fodder, as well as significantly reduced the relative change in rat weight for the high-fat diet. Furthermore, the presence of each tested vanadium complex had an impact of statistically significant increase in basal metabolic rate, regardless of applied diet. Further research on these organic vanadium complexes is necessary to understand the mechanisms responsible for their ability to affect adipose tissue.