A Brief Overview of miRNAs Orchestrating the Pathogenesis of Psoriasis


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Saygılı A., Çakır M., Açıkgöz E., Keskin S.

in: Advanced and Contemporary Studies in Health Sciences , Assoc. Prof. Sadettin DEMİREL, Editor, Duvar Yayınları, İzmir, pp.195-210, 2023

  • Publication Type: Book Chapter / Chapter Research Book
  • Publication Date: 2023
  • Publisher: Duvar Yayınları
  • City: İzmir
  • Page Numbers: pp.195-210
  • Editors: Assoc. Prof. Sadettin DEMİREL, Editor
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

Abstract

Psoriasis is a complex chronic inflammatory skin disorder triggered by environmental factors in genetically susceptible individuals. Genomic and immunological studies have guided the development of novel therapies. However, the mechanisms related to the pathophysiology of the chronic inflammatory process, particularly its association with the immune system and epigenetics, have not been fully elucidated. Summarizing miRNA alterations associated with psoriasis in recent studies could represent a groundbreaking revolution in understanding and treating the disease. microRNAs (miRNAs) are vital non-coding RNA molecules playing crucial roles in regulating gene expression within cells, with significant implications for biological processes and diseases. The discovery of miRNAs as variable small regulatory molecules in psoriasis has brought significant advancements. Previous studies have reported critical roles of miRNA alterations associated with the severity of psoriasis. Additionally, the mechanisms of action and functions of miRNAtargeted therapies remain a focal point of ongoing research in psoriasis. This section summarizes the alterations in miRNA molecules involved in psoriasis-related signaling pathways, the discovered miRNA biomarkers, and therapeutic targets, outlining potential directions for future functional studies. Moreover, it may facilitate the generation of new ideas among researchers interested in this field, thereby advancing translational therapies for psoriasis in the clinic and aiding in monitoring therapeutic responses.

Keywords: Psoriasis, miRNA, non-coding RNA, inflammation, immunity, keratinocyte