Protective Effects of Chrysin in Rats with Ovarian Torsion
KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI, cilt.27, sa.4, ss.417-424, 2021 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 27 Sayı: 4
- Basım Tarihi: 2021
- Doi Numarası: 10.9775/kvfd.2021.25357
- Dergi Adı: KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, Veterinary Science Database, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.417-424
- Anahtar Kelimeler: Ovary torsion, Chrysin, 8-OHdG, Antioxidant, GELATINASE-ASSOCIATED LIPOCALIN, ISCHEMIA-REPERFUSION INJURY, ACUTE KIDNEY INJURY, OXIDATIVE STRESS, ISCHEMIA/REPERFUSION INJURY, MODEL, INTERLEUKIN-18, FLAVONOIDS, DETORSION, TORSION/DETORSION
- Van Yüzüncü Yıl Üniversitesi Adresli: Evet
Özet
The objective of this study is to assess the protective effect of chrysin (CH) against ovarian torsion-detorsion injury. Thirty-two female albino rats were divided into 4 groups as Control, Torsion/Detorsion (T/D), TD-CH, and CH. Ovarian torsion was done for 3 hours on TD and TD-CH groups and then detorsion was performed. 50 mg/kg of CH was administered to the TD-CH group via oral gavage half an hour before the detorsion. Subsequently, 50 mg/kg of CH was administered via oral gavage to TD-CH and CH groups for 14 days. At the end of the experiment, blood samples were collected and ovarian tissue were taken. SOD and GPx activities and GSH and 8-OHdG levels were studied in serum and ovarian tissue. Also, IL-18, KIM-1, NGAL, Cys-C levels were studied in serum samples. GSH levels and GPx, SOD activities in both serum and ovarian tissue were significantly lower in TD group compared to the control and TD-CH groups (P<0.05), whereas the 8-OHdG level was significantly higher (P<0.05). Treatment with CH resulted in a decrease in 8-OHdG level and an increase in GSH level, GPx and SOD activities in both serum and ovarian tissue in the TD-CH group compared to TD group (P<0.05). Chrysin could ameliorate ovarian injury. Essentially, this outcome is thanks to the antioxidant, anti-inflammatory, and antiapoptotic effects of chrysin. Furthermore, it also has significant effects on DNA oxidative damage.