PAI-1 and tPA gene polymorphisms and susceptibility to chronic obstructive pulmonary disease in a sample of Turkish population

Sünnetçioğlu A., Berköz M., Yildirim M., Bora G., Yalin S.

Journal of the Pakistan Medical Association, cilt.70, sa.12 B, ss.2310-2315, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 70 Sayı: 12 B
  • Basım Tarihi: 2020
  • Doi Numarası: 10.47391/jpma.250
  • Dergi Adı: Journal of the Pakistan Medical Association
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.2310-2315
  • Anahtar Kelimeler: COPD, Genetic susceptibility, Plasminogen activator inhibitor-1 (PAI-1), Polymorphisms, Tissue-type plasminogen activator (tPA)
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

© 2020 Pakistan Medical Association. All rights reserved.Objective: The aim of this study was to assess the influence of plasminogen activator inhibitor-1 (PAI-1) 4G/5G or tissue plasminogen activator (tPA) I/D polymorphisms in chronic obstructive pulmonary disease (COPD) cases in a sample of Turkish population. Methods: PAI-1 4G/5G and tPA Alu-repeat I/D genetic polymorphisms in 153 COPD subjects and 160 controls were investigated using PCR-RFLP and PCR methods, respectively. Results: 4G allele frequency was 0.62 and 0.39 for COPD and control groups, respectively. 4G allele had an estimated 2.56-fold [95% CI = 1.85-3.53] increased risk of COPD. tPA I allele frequency was 0.55 and 0.50, for COPD and control groups, respectively. I allele had an estimated 1.19-fold [95% CI = 0.87-1.62] increased risk of COPD Conclusions: PAI-1 4G/4G and 4G/5G genotypes seemed to play a key role in the pathophysiology of COPD in Turkish individuals.