A simple one-pot synthesis of 1,2,3,4-tetrahydro-2-thioxopyrimidine derivatives


Akbaş E. , ASLANOGLU F. , ANIL B., SENER A.

JOURNAL OF HETEROCYCLIC CHEMISTRY, cilt.45, ss.1457-1460, 2008 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 45 Konu: 5
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1002/jhet.5570450532
  • Dergi Adı: JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Sayfa Sayıları: ss.1457-1460

Özet

5-Benzoyl-4-(substituted phenyl)-6-phenyl-1,2,3,4-tetrahydro-2-thioxopyrimidines (4a-d) were synthesized using the Biginelli three component cyclocondensation reaction of an appropriate beta-diketone, arylaldehyde, and thiourea in acetic acid under reflux condition in approximately 52-65% yields. The acetylation of compounds 4a-d gave 3-acetyl thioxopyrimidine derivatives 5a-d. Also, pyrimidothiazine compounds 6a-d were prepared by a simple one-pot condensation reaction of starting pyrimidine derivatives 4a-d and 3-bromopropionic acid. The structures of compounds were characterized on the basis of elemental analyses, IR,H-1 and C-13-NMR spectra.