Investigation of Matrix Metalloproteinas Levels In Preeclamptic/Eclamptic Pregnancy

Özmen E., Şahin H. G.

Eastern Journal of Medicine, vol.28, no.2, pp.307-313, 2023 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 2
  • Publication Date: 2023
  • Doi Number: 10.5505/ejm.2023.46872
  • Journal Name: Eastern Journal of Medicine
  • Journal Indexes: Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.307-313
  • Keywords: eclampsia, Matrix metalloproteinase, preeclampsia, pregnancy
  • Van Yüzüncü Yıl University Affiliated: Yes


The present research was designed to investigate levels of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), and their respective tissue inhibitors, tissue matrix metalloproteinase inhibitor-1 (TIMP-1) and tissue matrix metalloproteinase inhibitor-2 (TIMP-2), in eclamptic and preeclamptic pregnant women. In this work, undertaken in the Obstetrics and Gynecology Department of the Yüzüncü Yıl University Faculty of Medicine Health Practice and Research Hospital, eclamptic (n=28), preeclamptic (n=28), and healthy pregnant women (n=24) were enrolled and their levels of MMP-2, MMP-9, TIMP-1, and TIMP-2 were studied by micro-ELISA method. No statistically meaningful differences were identified between the study groups for MMP-2 (p=0.786). When the ratios of MMP-2 to TIMP-2 of the three groups were examined, again, no statistically meaningful differences were noted (p=0.788). While a meaningful difference was not seen between the preeclamptic and eclamptic groups for MMP-9 and TIMP-1, significantly lower values of MMP-9 and TIMP-1 were obtained in both groups upon comparison to the control group (p=0.001 for MMP-9, p<0.000 for TIMP-1). When the MMP-9/TIMP-1 ratios of the groups were evaluated, a statistically meaningful difference did not exist between women with preeclampsia and controls; however, this ratio was higher among women with eclampsia in comparison to the preeclampsia and control groups and this finding was statistically significantly (p=0.011). Imbalanced levels of MMP-9 and TIMP-1 could be used as a marker in efforts to predict preeclampsia and especially eclampsia. However, larger clinical studies are needed to reveal these interactions in more detail.