Efficient transfer hydrogenation reactions with quinazoline-based ruthenium complexes

Karabuga S., Bars S., Karakaya I., Gümüş S.

TETRAHEDRON LETTERS, vol.56, no.1, pp.101-104, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.1016/j.tetlet.2014.11.027
  • Journal Name: TETRAHEDRON LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.101-104
  • Keywords: Ruthenium, Quinazoline, Transfer hydrogenation, Ketone, Secondary alcohols, CATALYTIC TRANSFER HYDROGENATION, PYRAZOLYL-IMIDAZOLYL LIGAND, ARYL KETONES, BEARING, RU
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

(4-Phenylquinazolin-2-yl)methanamine was synthesized in high yield by starting from naturally and commercially available glycine in a few steps. The ligand was reacted with RuCl2(PPh3)(3) and RuCl2(PPh3) dppb to obtain N-heterocyclic ruthenium(II) complexes. We have examined these catalysts in transfer hydrogenation of acetophenone derivatives and excellent conversions of up to 99% and high TOF values of up to 118,800 h(-1) using 0.1 mol % of catalyst were achieved. (C) 2014 Elsevier Ltd. All rights reserved.