Oxidative stress and altered levels of antioxidants in adolescents with Down syndrome during pre-exercise and post-exercise

Ozbey U., Arslan C., SAVUCU Y., ERİŞİR M., Seyran A.

AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH, vol.6, no.27, pp.5625-5630, 2012 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 27
  • Publication Date: 2012
  • Doi Number: 10.5897/ajmr11.1621
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), CAB Abstracts, Veterinary Science Database
  • Page Numbers: pp.5625-5630
  • Van Yüzüncü Yıl University Affiliated: Yes


The aim of this study was to determine the influence of exercise on activity of erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and plasma malondialdehyde (MDA), beta-carotene, retinol levels in adolescents with Down syndrome (DS). Twenty adolescents with DS (14.86 +/- 7.07 years) performed a 12-week training program. Body composition was measured by bioelectric impedance method. SOD, GPx, CAT, MDA, retinol, beta-carotene levels was determined spectrophotometrically. When compared to baseline, MDA level was increased (P<0.05). SOD, GPx activities and beta-carotene level were decreased (P<0.05). There was no difference during pre-post exercise in terms of CAT activity and retinol level (P>0.05). The mean value of percentage of fat mass was reduced. Regular exercise decreased SOD, GPx activities and beta-carotene level and did not affect CAT activity and retinol level in individuals with DS. Exercise increases oxidative stress depending on level of training.