​Altered serum biomarkers of oxidative stress and antioxidant capacity in primary open-angle glaucoma

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Seven E., Tekin S., Demir C., Demir H., Batur M., Ozer M. D., ...More

Scientific Reports, vol.16, no.1, 2026 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 1
  • Publication Date: 2026
  • Doi Number: 10.1038/s41598-026-37221-7
  • Journal Name: Scientific Reports
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, MEDLINE, Directory of Open Access Journals
  • Keywords: Ischemia-modified albumin, Malondialdehyde, Oxidative stress, Primary open-angle glaucoma, Total thiol
  • Open Archive Collection: AVESIS Open Access Collection
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

This study investigated the role of oxidative stress in primary open-angle glaucoma (POAG) by comparing serum levels of ischemia-modified albumin (IMA), malondialdehyde (MDA), and total thiol (TT) between POAG patients and healthy controls. The study included 48 POAG patients and 54 age- and sex-matched healthy controls. Serum concentrations of IMA, MDA, and TT were measured using established assay methods. Statistical analysis revealed significantly higher levels of IMA and MDA and lower levels of TT in POAG patients than controls (p < 0.001). The findings show that patients with POAG tend to have higher oxidative stress levels and a weaker antioxidant defense system. This suggests that POAG patients are exposed to increased oxidative stress and lack sufficient antioxidants to counteract it. The imbalance between oxidants and antioxidants observed in these patients may indicate that oxidative stress plays a potential role in the development of the disease. Further population-based studies are necessary to clarify the causal relationship between these markers and the development or progression of POAG.