A Study on the Synthesis, Antimicrobial Activity, and Rapd Analysis of 3-phenyl-1,5-bis(4-(trifluoromethyl)phenyl)-1H-pyrazole

Cetin A., Bozari S.

JOURNAL OF BIOCHEMICAL TECHNOLOGY, vol.11, no.3, pp.77-83, 2020 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 3
  • Publication Date: 2020
  • Journal Indexes: Emerging Sources Citation Index (ESCI)
  • Page Numbers: pp.77-83
  • Keywords: Antibacterial, Amaranthus retroflexus, Germination experiment, Hordeum vulgare, PCR, Plant, BIOLOGICAL EVALUATION, FOOD SECURITY, CHALCONES, ANTICANCER, PESTICIDES
  • Van Yüzüncü Yıl University Affiliated: No


3-phenyl-1,5-bis(4-(trifluoromethyl)phenyl)-1H-pyrazole was synthesized and its structure was characterized by IR, NMR, and Elemental Analysis. The antimicrobial effects of pyrazole were investigated against seven bacteria (Bacillus subtilis ATCC 6633, Staphylococcus aureus 6538, Bacillus megaterium DSM 32 as gram-positive bacteria and Enterobacter aerogenes ATCC 13048, Pseudomonas aeruginosa 9027, Klebsiella pneumoniae RSKK 574 and Escherichia coli ATCC 25922) and three fungi organisms (Candida albicans ATCC 10231, Yarrovia lipolytica and Saccharomyces cerevisiae). Furthermore, the genomic stability values of designed pyrazole were observed in Hordeum vulgare and Amaranthus retroflexus L. from seeds based on random amplified-polymorphic DNA (RAPD) patterns compared to the five primers.