Corrigendum to "A New Approach in the Treatment of Traumatic Brain Injury: The Effects of Levosimendan on Necrosis, Apoptosis, and Oxidative Stress

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Aycan A., Öksüz E., Gönüllü E., Küme T., Ergür B. U., Akyol M. E., ...Daha Fazla

WORLD NEUROSURGERY, sa.1878, ss.432-441, 2023 (SCI-Expanded)

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2023
  • Dergi Adı: WORLD NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, Index Islamicus, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.432-441
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

Traumatic brain injury (TBI) is an essential

and common health problem worldwide. Levosimendan is

an inotropic and vasodilator drug used to treat heart failure.

Moreover, it exerts pleiotropic effects and, thus, protective

effects on many organs. The present study aimed to

investigate the effect of levosimendan on necrosis,

apoptosis, and reactive oxygen species in rats with TBI.

- METHODS: The study included 28 female Wistar-Albino

rats weighing 200e250 g. The rats were divided into 4

groups with 7 rats each as follows: Group 1: No trauma

group (Control), Group 2: Traumatized, untreated group (T),

Group 3: Levosimendan was administered at a dose of

12 mg/kg intraperitoneally 1 hour after the trauma (L1),

Group 4: Levosimendan was administered at a dose of

12 mg/kg intraperitoneally 2 hours after the concussion (L2).

After the experiment, the rats were decapitated, and the

brain tissue was removed. Necrosis was assessed with

Cresyl violet staining, apoptosis was assessed with

immunohistochemical analysis, superoxide dismutase and

catalase levels were measured with the spectrophotometric

method, and malondialdehyde (MDA) levels were

assessed by High-Performance Liquid Chromatography.

- RESULTS: The number of necrotic cells in the L1 and L2

groups was significantly lower than in the K and T groups

(P [ 0.015 and P [ 0.03, respectively). Although the active

caspase-3 level was signified considerably in the T, L1, and

L2 groups compared to the K group, no significant difference

was found among these 3 groups (P > 0.05). The results

of superoxide dismutase levels were similar to those

of active caspase-3. catalase level was significantly higher

in the K group than in the T and L2 groups (P [ 0.045).

Malondialdehyde activity was considerably higher in the

L1 and L2 groups compared to the K group (P [ 0.023).

-CONCLUSIONS: Our results indicated that levosimendan

may exert a neuroprotective effect by reducing necrosis in

TBI and that levosimendan does not affect apoptosis and

antioxidant levels in TBI. Comprehensive studies are

needed to elucidate the effect of levosimendan on TBI fully.