This study revealed some biochemical properties in the seeds and the fruit juice of twelve local grapevine cultivars-Karrod, Siyah gozane, Tayifi, Resealya, Heseni, Boga, Binetati, Beyaz sinciri, Askar, Emiri, Duvrevi, and Cicikenator. The colored and white grapes were categorized separately, and it was evaluated whether the skin color affected the biochemical content of the seed, and the compositions of the seeds were compared with the parallel samples taken from the juice. Total phenolic contents, proanthocyanidin contents, and total antioxidant capacities were also determined in the samples taken from the seeds and fruit juice for comparison purposes. The obtained results were mostly statistically significant [(P<0,01), (P<0,05)]. Considering the highest values detected in the seeds; the highest phenolic content was determined in cv. Binetati (87.30 GAE mg 100g-1 ); antioxidant capacity was in cv. Gozane (1344.86 mg g-1 ) and Proanthocyanidin value was in cv. Cicikenator (34.19 mg CE g-1 ).