A garlic oil-based organo-hydrogel for use in pH-sensitive drug release

Alpaslan D., Olak T., Turan A., Erşen Dudu T., Aktaş N.

CHEMICAL PAPERS, vol.75, no.11, pp.5759-5772, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 75 Issue: 11
  • Publication Date: 2021
  • Doi Number: 10.1007/s11696-021-01760-2
  • Journal Name: CHEMICAL PAPERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core
  • Page Numbers: pp.5759-5772
  • Keywords: Organo-hydrogel, Agar, Garlic oil, Ceftriaxone, Carboplatin, DELIVERY, SOLVENT, CONSTITUENTS, CARBOPLATIN, SURVIVAL, EFFICACY, IMMUNITY, AGAR
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

In this study, six different organo-hydrogels containing agar-glycerol (AG)-based garlic oil (GO) were synthesized using two different crosslinkers (N,N, methylenebisacrylamide (MBA), glutaraldehyde (GA)) to ensure the controlled release of ceftriaxone (Ce) and carboplatin (Cp). Synthesized organo-hydrogels were characterized by FT-IR. Afterward, swelling behaviors were investigated in DI, tap water, ethanol, acetone, ethanol/DI water (1:1), acetone/DI water (1:1) and gasoline environments and different pH. As a result of hemolysis, blood clotting and antioxidant analysis, organo-hydrogels have been shown to have blood compatibility and antioxidant properties. Ce and Cp release properties of the prepared organo-hydrogels were also determined. The highest Ce release rate was obtained to be 37.8% for p (AG-g-GO)(3) at pH 8.0 after 7 days. However, the highest Cp release rate was found to be 95.4% for p (AG-g-GO)(3) at pH 7.4 after 1 day.