Graphene/Nafion composite film modified glassy carbon electrode for simultaneous determination of paracetamol, aspirin and caffeine in pharmaceutical formulations

Yıgıt A., Yardım Y., Çelebi M., Levent A., Şentürk Z.

TALANTA, vol.158, pp.21-29, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 158
  • Publication Date: 2016
  • Doi Number: 10.1016/j.talanta.2016.05.046
  • Journal Name: TALANTA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.21-29
  • Keywords: Paracetamol, Aspirin, Caffeine, Graphene-Nafion composite film modified glassy carbon electrode, Pharmaceutical formulation, DOPED DIAMOND ELECTRODE, DIFFERENTIAL-PULSE VOLTAMMETRY, LIQUID-CHROMATOGRAPHIC METHODS, ACETYLSALICYLIC-ACID, ASCORBIC-ACID, ELECTROCHEMICAL-BEHAVIOR, SENSITIVE DETERMINATION, PASTE ELECTRODE, GRAPHITE OXIDE, SENSOR
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

A graphene-Nafion composite film was fabricated on the glassy carbon electrode (GR-NF/GCE), and used for simultaneous determination of paracetamol (PAR), aspirin (ASA) and caffeine (CAF). The electrochemical behaviors of PAR, ASA and CAF were investigated by cyclic voltammetry and square-wave adsorptive anodic stripping voltammetry. By using stripping one for simultaneous determination of PAR, ASA and CAF, their electrochemical oxidation peaks appeared at +0.64,1.04 and 1.44 V, and good linear current responses were obtained with the detection limits of 18 ng mL(-1) (1.2 x 10(-9) M), 11.7 ng mL(-1) (6.5 x 10(-8) M) and 7.3 ng mL(-1) (3.8 x 10(-8) M), respectively. Finally, the proposed electrochemical sensor was successfully applied for quantifying PAR, ASA and CAF in commercial tablet formulations. (C) 2016 Elsevier B.V. All rights reserved.