Graphene/Nafion composite film modified glassy carbon electrode for simultaneous determination of paracetamol, aspirin and caffeine in pharmaceutical formulations

Yıgıt A., Yardım Y., Çelebi M., Levent A., Şentürk Z.

TALANTA, cilt.158, ss.21-29, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 158
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.talanta.2016.05.046
  • Dergi Adı: TALANTA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.21-29
  • Anahtar Kelimeler: Paracetamol, Aspirin, Caffeine, Graphene-Nafion composite film modified glassy carbon electrode, Pharmaceutical formulation, DOPED DIAMOND ELECTRODE, DIFFERENTIAL-PULSE VOLTAMMETRY, LIQUID-CHROMATOGRAPHIC METHODS, ACETYLSALICYLIC-ACID, ASCORBIC-ACID, ELECTROCHEMICAL-BEHAVIOR, SENSITIVE DETERMINATION, PASTE ELECTRODE, GRAPHITE OXIDE, SENSOR
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

A graphene-Nafion composite film was fabricated on the glassy carbon electrode (GR-NF/GCE), and used for simultaneous determination of paracetamol (PAR), aspirin (ASA) and caffeine (CAF). The electrochemical behaviors of PAR, ASA and CAF were investigated by cyclic voltammetry and square-wave adsorptive anodic stripping voltammetry. By using stripping one for simultaneous determination of PAR, ASA and CAF, their electrochemical oxidation peaks appeared at +0.64,1.04 and 1.44 V, and good linear current responses were obtained with the detection limits of 18 ng mL(-1) (1.2 x 10(-9) M), 11.7 ng mL(-1) (6.5 x 10(-8) M) and 7.3 ng mL(-1) (3.8 x 10(-8) M), respectively. Finally, the proposed electrochemical sensor was successfully applied for quantifying PAR, ASA and CAF in commercial tablet formulations. (C) 2016 Elsevier B.V. All rights reserved.